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Proceedings Paper

Methodology development for simultaneous diffuse optical tomography and magnetic resonance imaging in functional human brain mapping
Author(s): Xiaofeng Zhang; Vladislav Y. Toronov; Andrew G. Webb
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Paper Abstract

We present an integrated methodology for human brain mapping by simultaneous BOLD fMRI and NIR imaging. This methodology consists of three innovative components: the construction of MRI-compatible optical probes that can be affixed to any part of the human head inside a standard MRI head-coil with minimal MR image distortion, the accurate determination of optode positions on the head from MR images, and the application of a perturbation approach and Monte Carlo method to compute the integral kernel of the Born solution to the diffusion equation for baseline optical properties. This integrated approach has been used to demonstrate promising capabilities for studying functional hemodynamic activation in human visual cortex by simultaneous fMRI and NIR tomography.

Paper Details

Date Published: 25 April 2005
PDF: 11 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.593432
Show Author Affiliations
Xiaofeng Zhang, Univ. of Illinois at Urbana-Champaign (United States)
Vladislav Y. Toronov, Univ. of Illinois at Urbana-Champaign (United States)
Andrew G. Webb, Univ. of Illinois at Urbana-Champaign (United States)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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