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Proceedings Paper

Optical characterization of vocal folds with optical coherence tomography
Author(s): Kathrin Luerssen; Holger Lubatschowski; Hagen Gasse; Rudiger Koch; Martin Ptok
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Paper Abstract

Optical coherence tomography (OCT) is a new non-invasive method to investigate biological tissue with a penetration depth of up to three millimeters. In this study OCT was used on the porcine larynx. The vocal folds were assigned to defined areas and examined by OCT followed by traditional histo-morphological analysis. We were able to validate this new method by showing that both the OCT-tomographs and the histological assays showed a clear demarcation of epithelium mucosae from the deeper layers. The current standard procedure to ensure the diagnosis, if tissue is malignant, is still an invasive one. Our results show that OCT allows the collection of crucial information about the quality of morphological changes on a vocal fold without the necessity of being invasive. Thus, we propose that optical coherence tomography should be introduced as a new and easy method for the detection of morphological changes of the vocal fold complementary to other established methods.

Paper Details

Date Published: 25 April 2005
PDF: 5 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.592630
Show Author Affiliations
Kathrin Luerssen, Hanover Medical School (Germany)
Holger Lubatschowski, Laser Zentrum Hannover e.V. (Germany)
Hagen Gasse, School of Veterinary Medicine Hanover (Germany)
Rudiger Koch, School of Veterinary Medicine Hanover (Germany)
Martin Ptok, Hanover Medical School (Germany)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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