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Proceedings Paper

Fluorescence-guided resections and photodynamic therapy for malignant gliomas using 5-aminolevulinic acid
Author(s): Herbert G. Stepp; Tobias Beck; Wolfgang Beyer; Thomas Pongratz; Ronald Sroka; Reinhold Baumgartner; Walter Stummer; Bernhard Olzowy; Jan Hinnerk Mehrkens; Joerg Christian Tonn; Hans Juergen Reulen
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Paper Abstract

Oral application of 20 mg/kg bw of 5-aminolevulinic acid results in a highly specific accumulation of fluorescent and phototoxic Protoporphyrin IX in malignant glioma tissue. Surgical removal with fluorescence guidance is studied in a phase III clinical trial, adjuvant Photodynamic Therapy (PDT) to the surgical cavity is in phase II and for interstitial PDT of recurrent gliomas, a phase I/II study has started. Fluorescence guided resections have been shown to be safe and effective in augmenting neurosurgical removal of malignant gliomas in 52 consecutive patients. Intra-operative fluorescence spectroscopy showed statistically significant higher sensitizer accumulation in vital brain tumor versus the infiltration zone and in the infiltration zone versus adjacent normal brain, which contained very little PPIX. This is promisingly exploited for PDT - both to the surgical cavity by surface irradiation and for stereotactically guided interstitial irradiation.

Paper Details

Date Published: 25 April 2005
PDF: 11 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.591526
Show Author Affiliations
Herbert G. Stepp, Univ. Clinic Munich (Germany)
Tobias Beck, Univ. Clinic Munich (Germany)
Wolfgang Beyer, Univ. Clinic Munich (Germany)
Thomas Pongratz, Univ. Clinic Munich (Germany)
Ronald Sroka, Univ. Clinic Munich (Germany)
Reinhold Baumgartner, Univ. Clinic Munich (Germany)
Walter Stummer, Univ. Hospital Duesseldorf (Germany)
Bernhard Olzowy, Univ. Clinic Munich (Germany)
Jan Hinnerk Mehrkens, Univ. Clinic Munich (Germany)
Joerg Christian Tonn, Univ. Clinic Munich (Germany)
Hans Juergen Reulen, Univ. Clinic Munich (Germany)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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