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Proceedings Paper

Optical coherence tomography and optical coherence domain reflectometry for deep brain stimulation probe guidance
Author(s): Sung W. Jeon; Mark A. Shure; Kenneth B. Baker; Ali Chahlavi; Nagi Hatoum; Massud Turbay; Andrew M. Rollins; Ali R. Rezai; David Huang
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Paper Abstract

Deep Brain Stimulation (DBS) is FDA-approved for the treatment of Parkinson's disease and essential tremor. Currently, placement of DBS leads is guided through a combination of anatomical targeting and intraoperative microelectrode recordings. The physiological mapping process requires several hours, and each pass of the microelectrode into the brain increases the risk of hemorrhage. Optical Coherence Domain Reflectometry (OCDR) in combination with current methodologies could reduce surgical time and increase accuracy and safety by providing data on structures some distance ahead of the probe. For this preliminary study, we scanned a rat brain in vitro using polarization-insensitive Optical Coherence Tomography (OCT). For accurate measurement of intensity and attenuation, polarization effects arising from tissue birefringence are removed by polarization diversity detection. A fresh rat brain was sectioned along the coronal plane and immersed in a 5 mm cuvette with saline solution. OCT images from a 1294 nm light source showed depth profiles up to 2 mm. Light intensity and attenuation rate distinguished various tissue structures such as hippocampus, cortex, external capsule, internal capsule, and optic tract. Attenuation coefficient is determined by linear fitting of the single scattering regime in averaged A-scans where Beer’s law is applicable. Histology showed very good correlation with OCT images. From the preliminary study using OCT, we conclude that OCDR is a promising approach for guiding DBS probe placement.

Paper Details

Date Published: 25 April 2005
PDF: 8 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.591159
Show Author Affiliations
Sung W. Jeon, Cleveland Clinic Foundation (United States)
Mark A. Shure, Cleveland Clinic Foundation (United States)
Kenneth B. Baker, Cleveland Clinic Foundation (United States)
Ali Chahlavi, Cleveland Clinic Foundation (United States)
Nagi Hatoum, Cleveland Clinic Foundation (United States)
Massud Turbay, Cleveland Clinic Foundation (United States)
Andrew M. Rollins, Case Western Reserve Univ. (United States)
Ali R. Rezai, Cleveland Clinic Foundation (United States)
David Huang, Univ. of Southern California (United States)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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