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Proceedings Paper

Preliminary observations on differences in the Raman spectra of cancerous and noncancerous cells and connective tissue of human skin
Author(s): Michael A. Short; Harvey Lui; David I. McLean; Haishan Zeng; Abdulmajeed Alajlan; Michael X. Chen
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Paper Abstract

A less invasive method of reliably detecting skin cancers is required. Raman spectroscopy is just one of several spectroscopic methods that look promising, but are not yet sufficiently reliable. More information is needed on how and why the Raman spectra of cancerous skin tissue is different from its normal counterpart. We have used confocal micro-Raman spectroscopy with a spatial resolution of about a micron to obtain spectra of unstained thin sections of human skin. We found that there were clear differences in the Raman spectra between cancerous and non-cancerous tissue both in cells and in the connective tissue. The DNA contribution to the spectra was generally stronger in malignant cells than normal ones. In regions of the dermis far away from the tumor one obtains the usual collagen spectra of normal skin, but adjacent to the tumor the spectra no longer appeared to be those of native collagen.

Paper Details

Date Published: 25 April 2005
PDF: 5 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.591076
Show Author Affiliations
Michael A. Short, Simon Fraser Univ. (Canada)
Harvey Lui, Univ. of British Columbia (Canada)
David I. McLean, Univ. of British Columbia (Canada)
Haishan Zeng, British Columbia Cancer Research Ctr. (Canada)
Abdulmajeed Alajlan, Univ. of British Columbia (Canada)
Michael X. Chen, Simon Fraser Univ. (Canada)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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