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Proceedings Paper

In vivo multiphoton tomography of inflammatory tissue and melanoma
Author(s): Iris Riemann; Enrico Dimitrow; Martin Kaatz; Joachim Fluhr; Peter Elsner; Jens Kobow; Karsten Konig
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Paper Abstract

Multiphoton optical tomography provides the capability of non-invasive optical sectioning of skin with high spatial and intracellular resolution as well as high NIR (near infrared) light penetration into pigmented skin areas. The imaging system DermaInspect based on femtosecond laser pulses was used to perform multiphoton optical tomography in clinical studies. Patients with abnormal pigmented tissues were imaged in vivo. After the multiphoton imaging procedure, biopsies were taken, imaged again and further processed with standard histological methods. We report on preliminary results. The visualization of pigmented cell clusters based on non-linear luminescence using the novel multiphoton device was possible. These clusters could be clearly distinguished from non-pigmented cells. Cancerous tissues showed significant differences in the cell structure of the epidermal layers. The system DermaInspect might become a high resolution diagnostic tool for melanoma diagnostics.

Paper Details

Date Published: 25 April 2005
PDF: 8 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.590533
Show Author Affiliations
Iris Riemann, Fraunhofer Institute for Biomedical Technology (Germany)
Enrico Dimitrow, Univ. Jena (Germany)
Martin Kaatz, Univ. Jena (Germany)
Joachim Fluhr, Univ. Jena (Germany)
Peter Elsner, Univ. Jena (Germany)
Jens Kobow, JenLab GmbH (Germany)
Karsten Konig, Fraunhofer Institute for Biomedical Technology (Germany)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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