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Technology and mechanism of neuron inactivation by N2 laser radiation (λ=337 nm), mercury-vapor lamp (Hg λ=365 nm), and low-coherence UV-A sun radiation
Author(s): Garif G. Akchurin; George G. Akchurin; George A. Seliverstov; Artyom Yu. Trofimov
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Paper Abstract

The method of the local functional injury of somatic frog's nerve using high coherent UV-A radiation of N2 laser (λ=337nm, P~10 mW), coherent mercury-vapor lamp radiation (λ=365; 312 nm PΣ~2 mW/cm2) and low-coherence UV-A sun radiation (400-315 nm, PΣ~10 mW) was realized. The level of injury was assessed from the decrease of compound action potential of the nerve stimulated extracellularly by electrical pulses of millisecond duration. Study of dynamic response of the bundle of axons revealed the decrease of the number of action potential which can be generated (less than 105). This decrease may be attributed to destruction of action transport and/or voltage-activated ion channels of axon membrane. The dose dependence of the level of nerve injury was studied using varied both intensity and duration of high and low-coherent UV-A irradiation.

Paper Details

Date Published: 25 April 2005
PDF: 7 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.589306
Show Author Affiliations
Garif G. Akchurin, Saratov State Univ. (Russia)
George G. Akchurin, Saratov State Univ. (Russia)
George A. Seliverstov, Saratov State Medical Univ. (Russia)
Artyom Yu. Trofimov, Saratov State Univ. (Russia)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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