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Proceedings Paper

Applications of multiphoton polarization and generalized polarization microscopy in elucidating transdermal delivery pathways
Author(s): Yen Sun; Jiunn-Wen Su; Wen Lo; Sung-Jan Lin; Shiou-Hwa Jee; Chen-Yuan Dong
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Paper Abstract

Physical and chemical enhancement techniques have proven to be useful in promoting transdermal delivery of therapeutic agents. However, it has been difficult to follow the changes to the skin during these processes microscopically. In this work, we use multiphoton polarization (P) and generalized polarization (GP) imaging of the membrane probe Laurdan to monitor changes to the stratum corneum under conditions of chemically enhanced delivery by oleic acid. We show that the combination of P and GP Laurdan imaging helps to reveal both the physical and chemical changes to the stratum corneum under enhanced delivery. Our work can help to develop more efficient transdermal delivery strategies.

Paper Details

Date Published: 25 April 2005
PDF: 8 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.587426
Show Author Affiliations
Yen Sun, National Taiwan Univ. (Taiwan)
Jiunn-Wen Su, National Taiwan Univ. (Taiwan)
Wen Lo, National Taiwan Univ. (Taiwan)
Sung-Jan Lin, National Taiwan Univ. Hospital (Taiwan)
Shiou-Hwa Jee, National Taiwan Univ. Hospital (Taiwan)
National Taiwan Univ. (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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