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Proceedings Paper

Heartbeat optical coherence tomography enables accurate in vivo stents imaging: a quantitative image processing study (Conference Presentation)
Author(s): Leonardo Cecchetti; Tianshi Wang; Tom Pfeiffer; Wolfgang Wieser; Antonius F. W. van der Steen; Robert Huber; Gijs van Soest; Robert Alexander Huber

Paper Abstract

Intravascular optical coherence tomography (IV-OCT) provides micrometer-order resolution images for interventional guidance, visualizing artery wall geometry and composition. We developed an ultrafast IV-OCT system, called Heartbeat OCT, providing accurate imaging of a coronary artery by completing a scan during the filling phase between two consecutive ventricular contractions. In this study we aim to quantify the imaging accuracy of the Heartbeat OCT by comparing the stents imaging results with a commercial OCT and a micro-CT. Two metal stents (Biotronik Orsiro) were implanted in the LAD artery of two male pigs. After 28 days, in vivo images were acquired using Heartbeat OCT and a commercial OCT system (Ilumien Optis, St. Jude Medical). After sacrificing the pigs, we acquired ex vivo images of the stents using a micro-CT, creating reference datasets for comparison. We conducted quantitative image processing studies in three steps. We first manually segmented the stents in OCT images. In the second step, a reference planar reconstruction of the stents was created based on the micro-CT images. In the third step, we counted, for each OCT pullback, the percentage of stents pixels that are located at < 80 µm from the reference structure. The results show that, in the two images acquired with Heartbeat OCT, 60% and 49% of stent strut locations matched with the reference micro-CT data. In the data from the commercial OCT system 48% and 51% spots matched with the reference data. In conclusion, Heartbeat OCT shows an 3D geometric imaging accuracy comparable or superior to that of the commercial OCT.

Paper Details

Date Published: 7 March 2019
Proc. SPIE 10855, Diagnostic and Therapeutic Applications of Light in Cardiology 2019, 1085506 (7 March 2019); doi: 10.1117/12.2513667
Show Author Affiliations
Leonardo Cecchetti, Erasmus MC (Netherlands)
Tianshi Wang, Erasmus MC (Netherlands)
Tom Pfeiffer, Univ. zu Lübeck (Germany)
Wolfgang Wieser, Optores GmbH (Germany)
Antonius F. W. van der Steen, Erasmus MC (Netherlands)
Shenzhen Institute of Advanced Technology (China)
Technische Univ. Delft (Netherlands)
Robert Huber, Univ. zu Lübeck (Germany)
Gijs van Soest, Erasmus MC (Netherlands)
Robert Alexander Huber, Univ. zu Lübeck (Germany)

Published in SPIE Proceedings Vol. 10855:
Diagnostic and Therapeutic Applications of Light in Cardiology 2019
Kenton W. Gregory M.D.; Laura Marcu, Editor(s)

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