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Proceedings Paper

Optimal acquisition setting for dual-contrast imaging with gadolinium and iodine on a research whole-body photon-counting-detector (PCD) CT
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Paper Abstract

Photon-counting detectors (PCDs) can resolve the energy of incident x-ray photons, which allows simultaneous imaging of two contrast materials, such as iodine (I) and gadolinium (Gd), with a single scan. This capability may allow reduction of patient radiation dose for clinical applications that typically require multi-phase acquisitions by injecting different contrast media at different times and scanning only once to differentiate, for example, venous and arterial phases. The material decomposition performance on PCD-CT is dependent on acquisition setup including tube potential and energy thresholds. In this work, we performed a phantom study to evaluate the optimal acquisition settings for dual-contrast imaging using I and Gd on a research PCD-CT system. We further compared our results with a clinical dual-source dual-energy (DSDE) CT. An abdomen-shaped water phantom with I and Gd inserts of different concentrations was scanned using different energy thresholds and tube potentials to identify the optimal setup for I and Gd quantification. Results demonstrated that accurate quantification of I and Gd concentration was possible using the PCD-CT system. A tube potential of 80 kV and an energy threshold close to the K-edge of Gd (50 keV) was found to yield the best performance in terms of measurement root-mean-square-error (RMSE = 4.4 mg/mL for I and RMSE = 3.3 mg/mL for Gd). Further, the performance of PCD-CT with optimized setup was found to outperform DSDE-CT (RMSE = 8.1 mg/mL for I and 5.7 mg/mL for Gd).

Paper Details

Date Published: 1 March 2019
PDF: 7 pages
Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109484I (1 March 2019); doi: 10.1117/12.2513454
Show Author Affiliations
Shengzhen Tao, Mayo Clinic (United States)
Yizhong Wu, Mayo Clinic (United States)
Kishore Rajendran, Mayo Clinic (United States)
Cynthia H. McCollough, Mayo Clinic (United States)
Shuai Leng, Mayo Clinic (United States)

Published in SPIE Proceedings Vol. 10948:
Medical Imaging 2019: Physics of Medical Imaging
Taly Gilat Schmidt; Guang-Hong Chen; Hilde Bosmans, Editor(s)

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