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Proceedings Paper

CT-guided PET parametric image reconstruction using deep neural network without prior training data
Author(s): Jianan Cui; Kuang Gong; Ning Guo; Kyungsang Kim; Huafeng Liu; Quanzheng Li
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Paper Abstract

Deep neural networks have attracted growing interests in medical image due to its success in computer vision tasks. One barrier for the application of deep neural networks is the need of large amounts of prior training pairs, which is not always feasible in clinical practice. Recently, the deep image prior framework shows that the convolutional neural network (CNN) can learn intrinsic structure information from the corrupted image. In this work, an iterative parametric reconstruction framework is proposed using deep neural network as constraint. The network does not need prior training pairs, but only the patient’s own CT image. The training is based on Logan plot derived from multi-bed-position dynamic positron emission tomography (PET) images using 68Ga-PRGD2 tracer. We formulated the estimation of the slope of Logan plot as a constraint optimization problem and solved it using the alternating direction method of multipliers (ADMM) algorithm. Quantification results based on real patient dataset shows that the proposed parametric reconstruction method is better than the Gaussian denoising and non-local mean denoising methods.

Paper Details

Date Published: 1 March 2019
PDF: 6 pages
Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109480Z (1 March 2019); doi: 10.1117/12.2513077
Show Author Affiliations
Jianan Cui, Zhejiang Univ. (China)
Massachusetts General Hospital (United States)
Kuang Gong, Gordon Ctr. for Medical Imaging, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Ning Guo, Gordon Ctr. for Medical Imaging, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Kyungsang Kim, Gordon Ctr. for Medical Imaging, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Huafeng Liu, Zhejiang Univ. (China)
Quanzheng Li, Gordon Ctr. for Medical Imaging, Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 10948:
Medical Imaging 2019: Physics of Medical Imaging
Taly Gilat Schmidt; Guang-Hong Chen; Hilde Bosmans, Editor(s)

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