Share Email Print

Proceedings Paper

First results developing time-of-flight proton radiography for proton therapy applications
Author(s): William A. Worstell; Bernhard W. Adams; Melvin Aviles; Justin Bond; Ethan Cascio; Till Cremer; Georges El Fakhri; Camden D. Ertley; Michael R. Foley; Kira S. Grogg; Cole J. Hamel; Hsiao-Ming Lu; Alexey V. Lyashenko; Michael J. Minot; Harald Paganetti; Mark A. Popecki; Michael E. Stochaj
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

In proton therapy treatment, proton residual energy after transmission through the treatment target may be determined by measuring sub-relativistic transmitted proton time-of-flight velocity and hence the residual energy. We have begun developing this method by conducting proton beam tests using Large Area Picosecond Photon Detectors (LAPPDs) which we have been developing for High Energy and Nuclear Physics Applications. LAPPDs are 20cm x 20cm area Micro Channel Plate Photomultiplier Tubes (MCP-PMTs) with millimeter-scale spatial resolution, good quantum efficiency and outstanding timing resolution of ≤70 picoseconds rms for single photoelectrons. We have constructed a time-of-flight telescope using a pair of LAPPDs at 10 cm separation, and have carried out our first tests of this telescope at the Massachusetts General Hospital's Francis Burr Proton Therapy Center. Treatment protons are sub-relativistic, so precise timing resolution can be combined with paired imaging detectors in a compact configuration while still yielding high accuracy in proton residual energy measurements through proton velocity determination from nearly monoenergetic protons. This can be done either for proton bunches or for individual protons. Tests were performed both in "ionization mode" using only the Microchannel Plates to detect the proton bunch structure and also in "photodetection mode" using nanosecond-decay-time quenched plastic scintillators to excite the photocathode within each of the paired LAPPDs. Data acquisition was performed using a remotely operated oscilloscope in our first beam test, and using 5Gsps DRS4 Evaluation Board waveform digitizers in our second test, in each case reading out both ends of single microstrips from among the 30 within an LAPPD. First results for this method and future plans are presented.

Paper Details

Date Published: 1 March 2019
PDF: 9 pages
Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109480G (1 March 2019); doi: 10.1117/12.2511804
Show Author Affiliations
William A. Worstell, Incom, Inc. (United States)
Bernhard W. Adams, Incom, Inc. (United States)
Melvin Aviles, Incom, Inc. (United States)
Justin Bond, Incom, Inc. (United States)
Ethan Cascio, Massachusetts General Hospital, Harvard Medical School (United States)
Till Cremer, Incom, Inc. (United States)
Georges El Fakhri, Massachusetts General Hospital, Harvard Medical School (United States)
Camden D. Ertley, Incom, Inc. (United States)
Michael R. Foley, Incom, Inc. (United States)
Kira S. Grogg, Massachusetts General Hospital, Harvard Medical School (United States)
Cole J. Hamel, Incom, Inc. (United States)
Hsiao-Ming Lu, Massachusetts General Hospital, Harvard Medical School (United States)
Alexey V. Lyashenko, Incom, Inc. (United States)
Michael J. Minot, Incom, Inc. (United States)
Harald Paganetti, Massachusetts General Hospital, Harvard Medical School (United States)
Mark A. Popecki, Incom, Inc. (United States)
Michael E. Stochaj, Incom, Inc. (United States)

Published in SPIE Proceedings Vol. 10948:
Medical Imaging 2019: Physics of Medical Imaging
Taly Gilat Schmidt; Guang-Hong Chen; Hilde Bosmans, Editor(s)

© SPIE. Terms of Use
Back to Top