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Proceedings Paper

Photoreceptor identification and quantitative analysis for the detection of retinal disease in AO-OCT imaging
Author(s): Elaine M. Wells-Gray; Stacey S. Choi; Matthew Ohr; Colleen M. Cebulla; Nathan Doble
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Paper Abstract

Adaptive optics (AO) enables imaging of cellular structures in the retina that are not visible with clinical imaging techniques, providing the potential for earlier detection of retinal disease and enhanced monitoring of progression. The aim of this work was to develop automated, quantitative techniques for characterizing the morphology of the posterior retina in AO-OCT B-scans. Images were obtained from a custom-built dual-modality AO-optical coherence tomographyscanning laser ophthalmoscopy (AO-OCT-SLO) imaging system. Automated segmentation and cone identification procedures were developed and applied to images from two groups: healthy controls and dry age-related macular degeneration (AMD) subjects. Results from the automated routines were compared to measurements made manually by an expert human reviewer, demonstrating good agreement. Results from the control subjects showed decreasing cone inner and outer segment lengths with increasing distance from the fovea. The cone outer segment tip (COST) layer had a greater variation in axial position compared to the inner segment/outer segment (IS/OS) junction. Results from the AMD group indicate that disruption in the COST layer over drusen occurs earlier and to a greater extent than the IS/OS junction, which may be useful in the detection of emerging drusen.

Paper Details

Date Published: 8 April 2019
PDF: 9 pages
Proc. SPIE 10858, Ophthalmic Technologies XXIX, 108580O (8 April 2019); doi: 10.1117/12.2510659
Show Author Affiliations
Elaine M. Wells-Gray, The Ohio State Univ. (United States)
Stacey S. Choi, The Ohio State Univ. (United States)
Matthew Ohr, The Ohio State Univ. (United States)
Colleen M. Cebulla, The Ohio State Univ. (United States)
Nathan Doble, The Ohio State Univ. (United States)

Published in SPIE Proceedings Vol. 10858:
Ophthalmic Technologies XXIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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