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Proceedings Paper

Intravascular near infrared spectroscopy for detection of lipid core plaque and structurally deficient plaque caps (Conference Presentation)
Author(s): Cherry Anne Greiner; Stephanie J. Grainger; Alexandra K. Gilligan; Samantha L. Farrow; Laura J. Healey; Sean P. Madden

Paper Abstract

Coronary artery disease (CAD) remains the world’s leading cause of death, causes widespread adverse effects on quality of life, and perpetuates massive healthcare spending. The involvement of lipid core plaques (LCPs) in CAD development, its progression, and acute coronary events has been well known for decades, yet detecting lipid core plaques in a living patient remains challenging. Detection of LCPs during the coronary catheterization procedure may lead to secondary prevention, reduction in procedural complications, and eventually the development of reliable non-invasive methods for primary prevention. Near infrared spectroscopy (NIRS) is widely used across numerous industries for rapid, non-destructive, remote identification of chemical compounds. Intravascular NIRS was developed for use during the coronary catheterization procedure and has been rigorously prospectively validated for a unique and novel diagnostic FDA claim for the detection of lipid core plaque. An additional important property of an LCP that is thought to significantly affect its vulnerability to rupture is the strength of the overlying collagen cap. New developments with intravascular NIRS suggest that it may additionally be useful for detection of structurally deficient collagen in LCP plaques, which are those that are most likely weak and more vulnerable to rupture. Updates will be given for the ongoing clinical utility of intravascular NIRS and the progress in the prospective validation of its capability to detect structurally deficient plaque caps.

Paper Details

Date Published: 7 March 2019
Proc. SPIE 10855, Diagnostic and Therapeutic Applications of Light in Cardiology 2019, 108550I (7 March 2019);
Show Author Affiliations
Cherry Anne Greiner, InfraReDx, Inc. (United States)
Stephanie J. Grainger, InfraReDx, Inc. (United States)
Alexandra K. Gilligan, InfraReDx, Inc. (United States)
Samantha L. Farrow, InfraReDx, Inc. (United States)
Laura J. Healey, InfraReDx, Inc. (United States)
Sean P. Madden, InfraReDx, Inc. (United States)

Published in SPIE Proceedings Vol. 10855:
Diagnostic and Therapeutic Applications of Light in Cardiology 2019
Kenton W. Gregory M.D.; Laura Marcu, Editor(s)

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