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Proceedings Paper

Nano sensitive study and fractal analysis of segmented retinal layers in Fourier domain OCT: promises for early disease detection
Author(s): Nandan Das; Sean O'Gorman; Sergey Alexandrov; Rajib Dey; Jay Chhablani; Nirmalya Ghosh; Martin Leahy
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Paper Abstract

Initial study found that depth-resolved refractive index variations encoded in retinal optical coherence tomography (OCT) exhibits multifractality. Interestingly, automated segmented different layers of the retina exhibited different degree of multifractality in a human eye. In an advanced study, we have adopted nano sensitive study of spectral contents of OCT signals before retinal image construction of a human eye. We have identified and constructed most contributed submicron structural spatial period OCT images. We have quantified nano structural morphological alteration in human retinal layers as deformation progress. This innovative approach promises to develop nano sensitive diagnostic tool for early disease detection in the human eye.

Paper Details

Date Published: 28 February 2019
PDF: 9 pages
Proc. SPIE 10858, Ophthalmic Technologies XXIX, 1085821 (28 February 2019); doi: 10.1117/12.2510410
Show Author Affiliations
Nandan Das, National Univ. of Ireland, Galway (Ireland)
Sean O'Gorman, National Univ. of Ireland, Galway (Ireland)
Sergey Alexandrov, National Univ. of Ireland, Galway (Ireland)
Rajib Dey, National Univ. of Ireland, Galway (Ireland)
Jay Chhablani, LV Prasad Eye Institute (India)
Nirmalya Ghosh, Indian Institute of Science Education and Research Kolkata (India)
Martin Leahy, National Univ. of Ireland, Galway (Ireland)

Published in SPIE Proceedings Vol. 10858:
Ophthalmic Technologies XXIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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