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Proceedings Paper

Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA) (Conference Presentation)
Author(s): Bingyao Tan; Jacqueline Chua; Amutha Barathi Veluchamy; Baskaran Mani; Anita Chan; Leopold Schmetterer

Paper Abstract

Choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In the recent years, there is an increasing interest to investigate choriocapillaris alteration and progression of eye diseases and aging, using the optical coherence tomography angiography (OCTA). However, standardized algorithm for analysis has not been developed. Herein, we present non-invasive, in-vivo, high-resolution images of the non-human primates’ choriocapillaris using OCTA. Images were acquired with a prototype swept-source OCTA (SS-OCTA) system with 100kHz A-scan/s rate, over regions of 3×3 mm2 and 12×12 mm2. The non-perfusion area, also called flow voids, were segmented with an intensity damped, illuminance-compensated algorithm. The optimized quantification of the choriocapillaris flow voids may have applications in a wide array of eye diseases including age-related macular degeneration (AMD) and visualization of choriocapillaris in animal models could aid future studies on choroid involvement in models of eye disease.

Paper Details

Date Published: 13 March 2019
Proc. SPIE 10858, Ophthalmic Technologies XXIX, 108580Q (13 March 2019); doi: 10.1117/12.2508708
Show Author Affiliations
Bingyao Tan, Singapore Eye Research Institute (Singapore)
Jacqueline Chua, Singapore Eye Research Institute (Singapore)
Duke-NUS Graduate Medical School (Singapore)
Amutha Barathi Veluchamy, Singapore Eye Research Institute (Singapore)
Duke-NUS Graduate Medical School (Singapore)
Baskaran Mani, Singapore Eye Research Institute (Singapore)
Anita Chan, Singapore Eye Research Institute (Singapore)
Leopold Schmetterer, Singapore Eye Research Institute (Singapore)
Duke-NUS Graduate Medical School (Singapore)
Nanyang Technological Univ. (Singapore)

Published in SPIE Proceedings Vol. 10858:
Ophthalmic Technologies XXIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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