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Proceedings Paper

Clinical Jones-matrix OCT for diagnosis of macular disease (Conference Presentation)
Author(s): Shinnosuke Azuma; Shuichi Makita; Masahiro Miura; Toshihiro Mino; Tatsuo Yamaguchi; Yoshiaki Yasuno

Paper Abstract

Jones matrix optical coherence tomography (JM-OCT) is a functional extension of OCT. However, the clinical utility of JM-OCT is not widely accepted. Because of its hardware complexity and poorly established methods for clinical interpretation. In this study, we propose the approaches to solve the above-mentioned problems. To reduce the hardware complexity, we employ encapsulated passive polarization delay module (PPD) and encapsulated polarization diversity detection module (PDD), and develop full-function JM-OCT and simplified JM-OCT. In addition, we developed a pixel wise segmentation method for JM-OCT. The full-function JM-OCT which uses both PDD and PPD measures OCT, OCT angiography (OCTA), degree-of-polarization-uniformity (DOPU) and birefringence. The simplified JM-OCT which uses only PDD measures OCT, OCTA, and DOPU but not birefringence. In both JM-OCT systems, all the optical components are packed in a standard-sized retinal scanner. A pixel-wise segmentation method for retinal pigment epithelium (RPE) and choroidal stroma exploits multiple types of images obtained by the JM-OCT. Attenuation coefficient, OCTA, and DOPU are combined to synthesize a new artificial contrast. By applying a simple threshold to it, the target tissue is segmented. After segmenting the RPE, an en face “melano-layer thickness map” is created. A Normal subject and a pigment epithelial detachment (PED) subject are obtained by full-function JM-OCT and simplified JM-OCT. In PED subject, thickened RPE, hyper-reflective foci, and damaged RPE are correctly detected by RPE segmentation. In addition, created melano-layer thickness map has similar patterns to infrared fundus autofluorescence (NIR-AF), and it can contribute further interpretation of the NIR-AF.

Paper Details

Date Published: 13 March 2019
Proc. SPIE 10858, Ophthalmic Technologies XXIX, 1085819 (13 March 2019); doi: 10.1117/12.2507800
Show Author Affiliations
Shinnosuke Azuma, Univ. of Tsukuba (Japan)
Shuichi Makita, Univ. of Tsukuba (Japan)
Masahiro Miura, Tokyo Medical Univ. (Japan)
Toshihiro Mino, Topcon Corp. (Japan)
Tatsuo Yamaguchi, Topcon Corp. (Japan)
Yoshiaki Yasuno, Univ. of Tsukuba (Japan)

Published in SPIE Proceedings Vol. 10858:
Ophthalmic Technologies XXIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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