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Proceedings Paper

Multidistance time domain diffuse optical spectroscopy in the assessment of abdominal fat heterogeneity
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Paper Abstract

A periodic monitoring of the adipose tissue functions due to interventions, such as calorie restriction and bariatric surgery, or pathophysiological processes, has an increasing relevance in clinical diagnostics. Diffuse Optical Spectroscopy (DOS) is a valuable non-invasive tool that can be used in that direction. In this work, we present a pilot study based on Time Domain Broadband Diffuse Optical Spectroscopy (TD DOS) to characterize in vivo the subcutaneous fat tissue in the abdominal region. A first of its kind, portable TD DOS instrumentation, already enrolled in clinical studies, was used. Three healthy male volunteers were considered. Three source-detector separation distances (1, 2, and 3 cm) were used over the broad wavelength range of 600-1100 nm. The analysis was performed using a method based on a heterogeneous model to account for the multi-layered nature of the subcutaneous adipose tissue, and to obtain the optical properties specific to this fat localization. Inter-subject variation of tissue composition data was observed.

Paper Details

Date Published: 17 May 2018
PDF: 7 pages
Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 1068513 (17 May 2018); doi: 10.1117/12.2307350
Show Author Affiliations
P. Lanka, Politecnico di Milano (Italy)
A. Farina , CNR-Istituto di Fotonica e Nanotecnologie (Italy)
S. Konugolu Venkata Sekar, Politecnico di Milano (Italy)
C. Guadagno , Politecnico di Milano (Italy)
L. Spinelli , CNR-Istituto di Fotonica e Nanotecnologie (Italy)
P. Taroni, Politecnico di Milano (Italy)
CNR-Istituto di Fotonica e Nanotecnologie (Italy)
R. Cubeddu , Politecnico di Milano (Italy)
E. Nisoli, Univ. degli Studi di Milano (Italy)
A. Pifferi, Politecnico di Milano (Italy)
CNR-Istituto di Fotonica e Nanotecnologie (Italy)

Published in SPIE Proceedings Vol. 10685:
Biophotonics: Photonic Solutions for Better Health Care VI
Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone, Editor(s)

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