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Proceedings Paper

Investigations and developments for PDT in brain tumors (Conference Presentation)

Paper Abstract

Malignant gliomas are a devastating brain tumor disease with very poor prognosis. Stereotactic biopsy sampling is routinely used in larger neurosurgical centers to confirm the diagnosis of a suspected brain tumor. This procedure is associated with risk of blood vessel rupture as well as false-negative results. Recent investigations suggest a potential of light-based techniques to improve both therapy and diagnosis of GBM. Optical guidance can be utilized to improve the biopsy sampling procedure in terms of safety, reliability, and efficacy. Recording of optical signals (transmission, remission, fluorescence) can be potentially integrated into a biopsy needle for providing optical detection of tumor tissue and blood vessel recognition during the biopsy sampling. Optical signals can also be used for monitoring purposes during photodynamic therapy. Here, fluorescence signals recorded before the treatment indicate the presence and accumulation level of photosensitizer, while photobleaching of the photosensitizer fluorescence during the treatment can be used as a measure of the effectiveness of the therapy. Finally, transmitted light can reveal problematic tissue-optical conditions as well as changes of the optical properties of the treated tissue, which may be relevant with regard to treatment prognosis and strategy. Different optical concepts for interstitial PDT monitoring and optical tissue property assessment are presented.

Paper Details

Date Published: 24 May 2018
Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 1068502 (24 May 2018); doi: 10.1117/12.2306925
Show Author Affiliations
Ronald Sroka, Laser-Forschungslabor (Germany)
Adrian Rühm, Laser-Forschungslabor (Germany)
Herbert Stepp, Laser-Forschungslabor (Germany)
Niklas Markwardt, Laser-Forschungslabor (Germany)

Published in SPIE Proceedings Vol. 10685:
Biophotonics: Photonic Solutions for Better Health Care VI
Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone, Editor(s)

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