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Proceedings Paper

Synchronous fluorescence spectroscopy with and without polarization sensitivity for colorectal cancer differentiation
Author(s): Ts. Genova; E. Borisova; N. Penkov M.D.; B. Vladimirov M.D.; L. Avramov
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Paper Abstract

In the present work the possible benefits of implementation of polarization sensitivity with synchronous fluorescence spectroscopy for differentiation of ex vivo colorectal tissue samples was evaluated. Synchronous fluorescence spectroscopy (SFS) is superior method for fluorescence analysis in comparison with standard fluorescence spectroscopy. Parallel and perpendicular linear fluorescence polarization, in respect to the polarization of the excitation light, was additionally applied with SFS. Same parameters based on the area of the most prominent fluorescence maxima for SFS without polarization, with parallel and perpendicular polarization, were compared. The introduced polarization sensitivity improves the statistically significant difference of some of the evaluated parameter for cancerous and healthy tissues and their potential application as diagnostic criteria.

Paper Details

Date Published: 17 May 2018
PDF: 9 pages
Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106852L (17 May 2018); doi: 10.1117/12.2306877
Show Author Affiliations
Ts. Genova, Institute of Electronics (Bulgaria)
E. Borisova, Institute of Electronics (Bulgaria)
N. Penkov M.D., Univ. Hospital “Tsaritsa Yoanna-ISUL” (Bulgaria)
B. Vladimirov M.D., Univ. Hospital "Tsaritsa Yoanna-ISUL" (Bulgaria)
L. Avramov, Institute of Electronics (Bulgaria)

Published in SPIE Proceedings Vol. 10685:
Biophotonics: Photonic Solutions for Better Health Care VI
Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone, Editor(s)

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