Share Email Print
cover

Proceedings Paper

Multiphoton tomography and multimodal OCT for in vivo visualization of oral malignancy in the hamster cheek pouch
Author(s): Vadim Elagin; Maria Karabut; Elena Kiseleva; Marina Sirotkina; Varvara Dudenkova; Nadezhda Pavlova; Sergey Kuznetsov; Lev Matveev; Alexander Moiseev; Anastasia Shumilova; Felix Feldchtein; Elena Zagaynova; Alex Vitkin; Natalia Gladkova
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

The main purpose of this work is to evaluate the possibility to distinguish in vivo benign papilloma, severe dysplasia and squamous cell carcinoma by establishing quantitative image characteristics of multiphoton tomography (MPT) and multimodal optical coherence tomography images (MM OCT). Specific features of papillomatous outgrowths at different stages were revealed using 7,12-dimethylbenz[a]anthracen (DMBA)-induced hamster oral carcinoma. Analysis of MPT images included assessment of nuclear-cytoplasmic (NC) ratio, nuclear density and heterogeneity parameter F. Crosspolarization OCT images were quantified via the integral depolarization factor (IDF). Analysis of OCT microvascular maps enabled differential analysis based on the number of smallest-diameter blood vessels present in a particular pathology. Both MPT and MM OCT metrics showed some difference between benign papilloma, dysplastic papilloma, and squamous cell carcinoma tissue states. The results suggested that combined use of MPT and MM OCT have great potential for in vivo differentiation between benign and malignant papillomas.

Paper Details

Date Published: 17 May 2018
PDF: 8 pages
Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106852T (17 May 2018); doi: 10.1117/12.2306210
Show Author Affiliations
Vadim Elagin, Privolzhsky Research Medical Univ. (Russian Federation)
Maria Karabut, Privolzhsky Research Medical Univ. (Russian Federation)
Elena Kiseleva, Privolzhsky Research Medical Univ. (Russian Federation)
Marina Sirotkina, Privolzhsky Research Medical Univ. (Russian Federation)
Varvara Dudenkova, Privolzhsky Research Medical Univ. (Russian Federation)
Lobachevsky State Univ. of Nizhni Novgorod (Russian Federation)
Nadezhda Pavlova, Privolzhsky Research Medical Univ. (Russian Federation)
Lobachevsky State Univ. of Nizhny Novgorod (Russian Federation)
Sergey Kuznetsov, Privolzhsky Research Medical Univ. (Russian Federation)
Lev Matveev, Privolzhsky Research Medical Univ. (Russian Federation)
Institute of Applied Physics (Russian Federation)
Alexander Moiseev, Privolzhsky Research Medical Univ. (Russian Federation)
Institute of Applied Physics (Russian Federation)
Anastasia Shumilova, Privolzhsky Research Medical Univ. (Russian Federation)
Lobachevsky State Univ. of Nizhni Novgorod (Russian Federation)
Felix Feldchtein, Privolzhsky Research Medical Univ. (Russian Federation)
Elena Zagaynova, Privolzhsky Research Medical Univ. (Russian Federation)
Alex Vitkin, Privolzhsky Research Medical Univ. (Russian Federation)
Univ. of Toronto (Canada)
Univ. Health Network (Canada)
Natalia Gladkova, Privolzhsky Research Medical Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10685:
Biophotonics: Photonic Solutions for Better Health Care VI
Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone, Editor(s)

© SPIE. Terms of Use
Back to Top