Share Email Print

Proceedings Paper

Breast elastography: Identification of benign and malignant cancer based on absolute elastic modulus measurement using vibro-elastography
Author(s): Junior Arroyo; Ana Cecilia Saavedra; Jorge Guerrero; Pilar Montenegro; Jorge Aguilar; Joseph A. Pinto; Julio Lobo; Tim Salcudean; Roberto Lavarello; Benjamín Castañeda
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Breast cancer is a public health problem with ~ 1.7 million new cases per year worldwide and with several limitations in the state-of-art screening techniques. Ultrasound elastography involves a set of techniques intended to facilitate the noninvasive diagnosis of cancer. Among these, Vibro-elastography is an ultrasound-based technique that employs external mechanical excitation to infer the elastic properties of soft tissue. In this paper, we evaluate the Vibro-elastography performance in the differentiation of benign and malignant breast lesions. For this study, a group of 18 women with clinically confirmed tumors or suspected malignant breast lesions were invited to participate. For each volunteer, an elastogram was obtained, and the mean elasticity of the lesion and the adjacent healthy tissue were calculated. After the acquisition, the volunteers underwent core-needle biopsy. The histopathological results allowed to validate the Vibro-elastography diagnosis, which ranged from benign to malignant lesions. Results indicate that the mean elasticity value of the benign lesions, malignant lesions and healthy breast tissue were 39.4 ± 12 KPa, 55.4 ± 7.02 KPa and 23.91 ± 4.57 kPa, respectively. The classification between benign and malignant breast cancer was performed using Support Vector Machine based on the measured lesion stiffness. A ROC curve permitted to quantify the accuracy of the differentiation and to define a suitable cutoff value of stiffness, obtaining an AUC of 0.90 and a cutoff value of 44.75 KPa. The results obtained suggest that Vibro-elastography allows differentiating between benign and malignant lesions. Furthermore, the elasticity values obtained for benign, malignant and healthy tissue are consistent with previous reports.

Paper Details

Date Published: 7 March 2018
PDF: 8 pages
Proc. SPIE 10577, Medical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment, 105771E (7 March 2018);
Show Author Affiliations
Junior Arroyo, Pontificia Univ. Católica del Perú (Peru)
Ana Cecilia Saavedra, Pontificia Univ. Católica del Perú (Peru)
Jorge Guerrero, Oncosalud (Peru)
Pilar Montenegro, Oncosalud (Peru)
Jorge Aguilar, Oncosalud (Peru)
Joseph A. Pinto, Oncosalud (Peru)
Julio Lobo, The Univ. of British Columbia (Canada)
Tim Salcudean, The Univ. of British Columbia (Canada)
Roberto Lavarello, Pontificia Univ. Católica del Perú (Peru)
Benjamín Castañeda, Pontificia Univ. Católica del Perú (Peru)

Published in SPIE Proceedings Vol. 10577:
Medical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment
Robert M. Nishikawa; Frank W. Samuelson, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?