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Proceedings Paper

Deep learning of contrast-coated serrated polyps for computer-aided detection in CT colonography
Author(s): Janne J. Näppi; Perry Pickhardt; David H. Kim; Toru Hironaka; Hiroyuki Yoshida
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Paper Abstract

Serrated polyps were previously believed to be benign lesions with no cancer potential. However, recent studies have revealed a novel molecular pathway where also serrated polyps can develop into colorectal cancer. CT colonography (CTC) can detect serrated polyps using the radiomic biomarker of contrast coating, but this requires expertise from the reader and current computer-aided detection (CADe) systems have not been designed to detect the contrast coating. The purpose of this study was to develop a novel CADe method that makes use of deep learning to detect serrated polyps based on their contrast-coating biomarker in CTC. In the method, volumetric shape-based features are used to detect polyp sites over soft-tissue and fecal-tagging surfaces of the colon. The detected sites are imaged using multi-angular 2D image patches. A deep convolutional neural network (DCNN) is used to review the image patches for the presence of polyps. The DCNN-based polyp-likelihood estimates are merged into an aggregate likelihood index where highest values indicate the presence of a polyp. For pilot evaluation, the proposed DCNN-CADe method was evaluated with a 10-fold cross-validation scheme using 101 colonoscopy-confirmed cases with 144 biopsy-confirmed serrated polyps from a CTC screening program, where the patients had been prepared for CTC with saline laxative and fecal tagging by barium and iodine-based diatrizoate. The average per-polyp sensitivity for serrated polyps ≥6 mm in size was 93±7% at 0:8±1:8 false positives per patient on average. The detection accuracy was substantially higher that of a conventional CADe system. Our results indicate that serrated polyps can be detected automatically at high accuracy in CTC.

Paper Details

Date Published: 3 March 2017
PDF: 7 pages
Proc. SPIE 10134, Medical Imaging 2017: Computer-Aided Diagnosis, 101340H (3 March 2017); doi: 10.1117/12.2255634
Show Author Affiliations
Janne J. Näppi, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Perry Pickhardt, Univ. of Wisconsin School of Medicine and Public Health (United States)
David H. Kim, Univ. of Wisconsin School of Medicine and Public Health (United States)
Toru Hironaka, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Hiroyuki Yoshida, Massachusetts General Hospital (United States)
Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 10134:
Medical Imaging 2017: Computer-Aided Diagnosis
Samuel G. Armato III; Nicholas A. Petrick, Editor(s)

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