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Proceedings Paper

An x-ray-based capsule for colorectal cancer screening incorporating single photon counting technology
Author(s): Ronen Lifshitz; Yoav Kimchy; Nir Gelbard; Avi Leibushor; Oleg Golan; Avner Elgali; Salah Hassoon; Max Kaplan; Michael Smirnov; Boaz Shpigelman; Omer Bar-Ilan; Daniel Rubin; Alex Ovadia
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Paper Abstract

An ingestible capsule for colorectal cancer screening, based on ionizing-radiation imaging, has been developed and is in advanced stages of system stabilization and clinical evaluation. The imaging principle allows future patients using this technology to avoid bowel cleansing, and to continue the normal life routine during procedure. The Check-Cap capsule, or C-Scan ® Cap, imaging principle is essentially based on reconstructing scattered radiation, while both radiation source and radiation detectors reside within the capsule. The radiation source is a custom-made radioisotope encased in a small canister, collimated into rotating beams. While traveling along the human colon, irradiation occurs from within the capsule towards the colon wall. Scattering of radiation occurs both inside and outside the colon segment; some of this radiation is scattered back and detected by sensors onboard the capsule. During procedure, the patient receives small amounts of contrast agent as an addition to his/her normal diet. The presence of contrast agent inside the colon dictates the dominant physical processes to become Compton Scattering and X-Ray Fluorescence (XRF), which differ mainly by the energy of scattered photons. The detector readout electronics incorporates low-noise Single Photon Counting channels, allowing separation between the products of these different physical processes. Separating between radiation energies essentially allows estimation of the distance from the capsule to the colon wall, hence structural imaging of the intraluminal surface. This allows imaging of structural protrusions into the colon volume, especially focusing on adenomas that may develop into colorectal cancer.

Paper Details

Date Published: 9 March 2017
PDF: 10 pages
Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101321O (9 March 2017); doi: 10.1117/12.2254242
Show Author Affiliations
Ronen Lifshitz, Check-Cap Ltd. (Israel)
Yoav Kimchy, Check-Cap Ltd. (Israel)
Nir Gelbard, Check-Cap Ltd. (Israel)
Avi Leibushor, Check-Cap Ltd. (Israel)
Oleg Golan, Check-Cap Ltd. (Israel)
Avner Elgali, Check-Cap Ltd. (Israel)
Salah Hassoon, Check-Cap Ltd. (Israel)
Max Kaplan, Check-Cap Ltd. (Israel)
Michael Smirnov, Check-Cap Ltd. (Israel)
Boaz Shpigelman, Check-Cap Ltd. (Israel)
Omer Bar-Ilan, Check-Cap Ltd. (Israel)
Daniel Rubin, Check-Cap Ltd. (Israel)
Alex Ovadia, Check-Cap Ltd. (Israel)

Published in SPIE Proceedings Vol. 10132:
Medical Imaging 2017: Physics of Medical Imaging
Thomas G. Flohr; Joseph Y. Lo; Taly Gilat Schmidt, Editor(s)

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