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Proceedings Paper

Minimally invasive optical biopsy for oximetry
Author(s): Marieke A. van der Putten; James M. Brewer; Andrew R. Harvey
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Paper Abstract

The study of localised oxygen saturation in blood vessels can shed light on the etiology and progression of many diseases with which hypoxia is associated. For example, hypoxia in the tendon has been linked to early stages of rheumatoid arthritis, an auto-immune inflammatory disease. Vascular oximetry of deep tissue presents significant challenges as vessels are not optically accessible. In this paper, we present a novel multispectral imaging technique for vascular oximetry, and recent developments made towards its adaptation for minimally invasive imaging. We present proof-of-concept of the system and illumination scheme as well as the analysis technique. We present results of a validation study performed in vivo on mice with acutely inflamed tendons. Adaptation of the technique for minimally invasive microendoscopy is also presented, along with preliminary results of minimally invasive ex vivo vascular oximetry.

Paper Details

Date Published: 15 February 2017
PDF: 8 pages
Proc. SPIE 10040, Endoscopic Microscopy XII, 1004009 (15 February 2017); doi: 10.1117/12.2253645
Show Author Affiliations
Marieke A. van der Putten, Univ. of Glasgow (United Kingdom)
James M. Brewer, Univ. of Glasgow (United Kingdom)
Andrew R. Harvey, Univ. of Glasgow (United Kingdom)

Published in SPIE Proceedings Vol. 10040:
Endoscopic Microscopy XII
Guillermo J. Tearney M.D.; Thomas D. Wang, Editor(s)

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