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Proceedings Paper

Assessing the mechanical anisotropy and hysteresis while cycling IOP of porcine eyes before and after CXL by noncontact optical coherence elastography
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Paper Abstract

Diseases such as keratoconus can alter the orientation of collagen fibrils in the cornea. Moreover, therapeutic interventions such as UV-A/riboflavin corneal collagen crosslinking (CXL) can alter the collagen fibril arrangement. Therefore, the anisotropic characteristics of the cornea can provide vital information about tissue integrity. In this work, we utilize noncontact elastic wave imaging optical coherence elastography (EWI-OCE) to assess the elastic anisotropy and hysteresis of in situ porcine corneas as various intraocular pressures (IOP). In addition, we evaluated the effects of CXL on the mechanical anisotropy and hysteresis. OCE measurements were made at stepped meridional angles, and a sliding window algorithm spatially mapped the elasticity. A modified planar anisotropy coefficient was utilized to quantify the elastic anisotropy of the corneas. The results show that the stiffness and elastic anisotropy of the corneas were significantly affected by CXL and IOP (P<0.001), but the hysteresis was not significant (P<0.05). Moreover, the changes in elasticity due to CXL were angle-dependent (P<0.005). However, the changes in mechanical anisotropy from CXL were not angle-dependent (P>0.05).

Paper Details

Date Published: 8 February 2017
PDF: 7 pages
Proc. SPIE 10045, Ophthalmic Technologies XXVII, 1004504 (8 February 2017); doi: 10.1117/12.2253433
Show Author Affiliations
Manmohan Singh, Univ. of Houston (United States)
Jiasong Li, Univ. of Houston (United States)
Raksha Raghunathan, Univ. of Houston (United States)
Zhaolong Han, Univ. of Houston (United States)
Achuth Nair, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Salavt R. Aglyamov, The Univ. of Texas at Austin (United States)
Michael D. Twa, The Univ. of Alabama at Birmingham (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 10045:
Ophthalmic Technologies XXVII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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