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Proceedings Paper

Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen
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Paper Abstract

Effective photodynamic therapy (PDT) treatment planning and treatment monitoring requires computer simulations of both light transport in tissue and photosensitizer (PS) photophysics to accurately estimate singlet oxygen. Simply using fixed prescribed values of light dose (fluence) or PDT dose (the time integral of ‘PS concentration’ times the ‘fluence rate’) – one value for all patients – does not account for differences in the amount of singlet oxygen formed when fluence rates change or patient tissue parameters change. We will focus on singlet oxygen dose which is calculated by solving the photokinetics rate equations and which determines the effectiveness of the subsequent reactions of singlet oxygen with the cancer target and the negative effect of PS photobleaching.

Paper Details

Date Published: 8 February 2017
PDF: 10 pages
Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 100470R (8 February 2017); doi: 10.1117/12.2252552
Show Author Affiliations
Karl Beeson, Simphotek Inc. (United States)
Evgueni Parilov, Simphotek Inc. (United States)
Mary Potasek, Simphotek Inc. (United States)


Published in SPIE Proceedings Vol. 10047:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
David H. Kessel; Tayyaba Hasan, Editor(s)

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