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Proceedings Paper

Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging
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Paper Abstract

We describe a novel, multi-modal imaging protocol for validating quantitative dynamic airway imaging performed using anatomical Optical Coherence Tomography (aOCT). The aOCT system consists of a catheter-based aOCT probe that is deployed via a bronchoscope, while a programmable ventilator is used to control airway pressure. This setup is employed on the bed of a Siemens Biograph CT system capable of performing respiratory-gated acquisitions. In this arrangement the position of the aOCT catheter may be visualized with CT to aid in co-registration. Utilizing this setup we investigate multiple respiratory pressure parameters with aOCT, and respiratory-gated CT, on both ex vivo porcine trachea and live, anesthetized pigs. This acquisition protocol has enabled real-time measurement of airway deformation with simultaneous measurement of pressure under physiologically relevant static and dynamic conditions- inspiratory peak or peak positive airway pressures of 10-40 cm H2O, and 20-30 breaths per minute for dynamic studies. We subsequently compare the airway cross sectional areas (CSA) obtained from aOCT and CT, including the change in CSA at different stages of the breathing cycle for dynamic studies, and the CSA at different peak positive airway pressures for static studies. This approach has allowed us to improve our acquisition methodology and to validate aOCT measurements of the dynamic airway for the first time. We believe that this protocol will prove invaluable for aOCT system development and greatly facilitate translation of OCT systems for airway imaging into the clinical setting.

Paper Details

Date Published: 14 February 2017
PDF: 9 pages
Proc. SPIE 10039, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology, 1003907 (14 February 2017); doi: 10.1117/12.2250348
Show Author Affiliations
Santosh Balakrishnan, The Univ. of North Carolina at Chapel Hill (United States)
Ruofei Bu, The Univ. of North Carolina at Chapel Hill (United States)
Hillel Price, The Univ. of North Carolina at Chapel Hill (United States)
Carlton Zdanski, The Univ. of North Carolina at Chapel Hill (United States)
Amy L. Oldenburg, The Univ. of North Carolina at Chapel Hill (United States)


Published in SPIE Proceedings Vol. 10039:
Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology
Brian J. F. Wong M.D.; Justus F. Ilgner M.D.; Krzysztof Izdebski, Editor(s)

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