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Proceedings Paper

Detection of microcalcification clusters by 2D-mammography and narrow and wide angle digital breast tomosynthesis
Author(s): Andria Hadjipanteli; Premkumar Elangovan; Padraig T. Looney; Alistair Mackenzie; Kevin Wells; David R. Dance; Kenneth C. Young
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Paper Abstract

The aim of this study was to compare the detection of microcalcification clusters by human observers in breast images using 2D-mammography and narrow (15°/15 projections) and wide (50°/25 projections) angle digital breast tomosynthesis (DBT). Simulated microcalcification clusters with a range of microcalcification diameters (125 μm-275 μm) were inserted into 6 cm thick simulated compressed breasts. Breast images were produced with and without inserted microcalcification clusters using a set of image modelling tools, which were developed to represent clinical imaging by mammography and tomosynthesis. Commercially available software was used for image processing and image reconstruction. The images were then used in a series of 4-alternative forced choice (4AFC) human observer experiments conducted for signal detection with the microcalcification clusters as targets. The minimum detectable calcification diameter was found for each imaging modality: (i) 2D-mammography: 164±5 μm (ii) narrow angle DBT: 210±5 μm, (iii) wide angle DBT: 255±4 μm. A statistically significant difference was found between the minimum detectable calcification diameters that can be detected by the three imaging modalities. Furthermore, it was found that there was not a statistically significant difference between the results of the five observers that participated in this study. In conclusion, this study presents a method that quantifies the threshold diameter required for microcalcification detection, using high resolution, realistic images with observers, for the comparison of DBT geometries with 2D-mammography. 2Dmammography can visualise smaller detail diameter than both DBT imaging modalities and narrow-angle DBT can visualise a smaller detail diameter than wide-angle DBT.

Paper Details

Date Published: 22 March 2016
PDF: 8 pages
Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 978306 (22 March 2016); doi: 10.1117/12.2217663
Show Author Affiliations
Andria Hadjipanteli, The Royal Surrey County Hospital (United Kingdom)
Premkumar Elangovan, Univ. of Surrey (United Kingdom)
Padraig T. Looney, The Royal Surrey County Hospital (United Kingdom)
Alistair Mackenzie, The Royal Surrey County Hospital (United Kingdom)
Kevin Wells, Univ. of Surrey (United Kingdom)
David R. Dance, The Royal Surrey County Hospital (United Kingdom)
Univ. of Surrey (United Kingdom)
Kenneth C. Young, The Royal Surrey County Hospital (United Kingdom)
Univ. of Surrey (United Kingdom)

Published in SPIE Proceedings Vol. 9783:
Medical Imaging 2016: Physics of Medical Imaging
Despina Kontos; Thomas G. Flohr, Editor(s)

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