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Proceedings Paper

High-definition Fourier transform infrared spectroscopic imaging of prostate tissue
Author(s): Tomasz P. Wrobel; Jin Tae Kwak; Andre Kadjacsy-Balla; Rohit Bhargava
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Paper Abstract

Histopathology forms the gold standard for cancer diagnosis and therapy, and generally relies on manual examination of microscopic structural morphology within tissue. Fourier-Transform Infrared (FT-IR) imaging is an emerging vibrational spectroscopic imaging technique, especially in a High-Definition (HD) format, that provides the spatial specificity of microscopy at magnifications used in diagnostic surgical pathology. While it has been shown for standard imaging that IR absorption by tissue creates a strong signal where the spectrum at each pixel is a quantitative “fingerprint” of the molecular composition of the sample, here we show that this fingerprint also enables direct digital pathology without the need for stains or dyes for HD imaging. An assessment of the potential of HD imaging to improve diagnostic pathology accuracy is presented.

Paper Details

Date Published: 23 March 2016
PDF: 7 pages
Proc. SPIE 9791, Medical Imaging 2016: Digital Pathology, 97911D (23 March 2016); doi: 10.1117/12.2217341
Show Author Affiliations
Tomasz P. Wrobel, Univ. of Illinois at Urbana-Champaign (United States)
Jin Tae Kwak, National Institutes of Health (United States)
Andre Kadjacsy-Balla, Univ. of Illinois at Chicago (United States)
Univ. of Illinois Cancer Ctr. (United States)
Rohit Bhargava, Univ. of Illinois at Urbana-Champaign (United States)
Univ. of Illinois Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 9791:
Medical Imaging 2016: Digital Pathology
Metin N. Gurcan; Anant Madabhushi, Editor(s)

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