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Proceedings Paper

Finding regional models of the Alzheimer disease by fusing information from neuropsychological tests and structural MR images
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Paper Abstract

Initial diagnosis of Alzheimer's disease (AD) is based on the patient's clinical history and a battery of neuropsy-chological tests. This work presents an automatic strategy that uses Structural Magnetic Resonance Imaging (MRI) to learn brain models for different stages of the disease using information from clinical assessments. Then, a comparison of the discriminant power of the models in different anatomical areas is made by using the brain region of the models as a reference frame for the classification problem, by using the projection into the AD model a Receiver Operating Characteristic (ROC) curve is constructed. Validation was performed using a leave- one-out scheme with 86 subjects (20 AD and 60 NC) from the Open Access Series of Imaging Studies (OASIS) database. The region with the best classification performance was the left amygdala where it is possible to achieve a sensibility and specificity of 85% at the same time. The regions with the best performance, in terms of the AUC, are in strong agreement with those described as important for the diagnosis of AD in clinical practice.

Paper Details

Date Published: 24 March 2016
PDF: 6 pages
Proc. SPIE 9785, Medical Imaging 2016: Computer-Aided Diagnosis, 97852H (24 March 2016); doi: 10.1117/12.2217021
Show Author Affiliations
Diana L. Giraldo, Univ. Nacional de Colombia (Colombia)
Juan D. García-Arteaga, Univ. Nacional de Colombia (Colombia)
Eduardo Romero M.D., Univ. Nacional de Colombia (Colombia)

Published in SPIE Proceedings Vol. 9785:
Medical Imaging 2016: Computer-Aided Diagnosis
Georgia D. Tourassi; Samuel G. Armato III, Editor(s)

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