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Proceedings Paper

Potential use of microbubbles (MBs) as contrast material in x-ray dark field (DF) imaging: How does the DF signal change with the characteristic parameters of the MBs?
Author(s): Ran Zhang; Bin Qin; Yongshuai Ge; Bruce Whiting; Ke Li; Flordeliza Villanueva; Guang-Hong Chen
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Paper Abstract

One of the most exciting aspects of the grating based x-ray differential phase contrast (DPC) acquisition method is the concurrent generation of the so-called dark field (DF) signal, along with the classical absorption signal and the novel DPC signal. The DF signal is associated with local distribution of small angle scatterers in an image object, while the absorption signal and DPC signal are often used to characterize the relatively uniform structure of the image object. Besides the endogenous image contrast, exogenous contrast media are often used in x-ray imaging to locally enhance the image signal. This paper proposes a potential contrast medium for DF signal enhancement: microbubbles (MBs). MBs have already been developed for clinical use in ultrasound imaging, and recent experimental studies have shown that MBs may also enhance the DF signal, although it remained unclear how the physical characteristics of the MBs quantitatively impact the DF signal. In this paper, a systematic study was performed to investigate the quantitative relationships between the DF signal and the following properties of MBs: size, concentration, shell thickness, size uniformity, and whether gold nanoparticles were attached. The experimental results demonstrated that, an increased MB size (about 4 microns) may generate a stronger DF signal for our DPC imaging system; additionally, a moderately increased shell thickness and the use of gold nanoparticles on the shell surface also resulted in further enhancement of the DF signal. These findings may provide critical information needed for using MBs as the contrast agent of x-ray DF imaging.

Paper Details

Date Published: 22 March 2016
PDF: 7 pages
Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97830N (22 March 2016); doi: 10.1117/12.2216322
Show Author Affiliations
Ran Zhang, Univ. of Wisconsin School of Medicine and Public Health (United States)
Bin Qin, Univ. of Pittsburgh (United States)
Yongshuai Ge, Univ. of Wisconsin School of Medicine and Public Health (United States)
Bruce Whiting, Univ. of Pittsburgh (United States)
Ke Li, Univ. of Wisconsin School of Medicine and Public Health (United States)
Flordeliza Villanueva, Univ. of Pittsburgh (United States)
Guang-Hong Chen, Univ. of Wisconsin School of Medicine and Public Health (United States)

Published in SPIE Proceedings Vol. 9783:
Medical Imaging 2016: Physics of Medical Imaging
Despina Kontos; Thomas G. Flohr, Editor(s)

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