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Proceedings Paper

Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells
Author(s): Catherine E. Christie M.D.; Qian Peng M.D.; Steen J. Madsen III; Francisco A. Uzal; Henry Hirschberg M.D.
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Paper Abstract

Immunotherapy of brain tumors involves the stimulation of an antitumor immune response. This type of therapy can be targeted specifically to tumor cells thus sparing surrounding normal brain. Due to the presence of the blood-brain barrier, the brain is relatively isolated from the systemic circulation and, as such, the initiation of significant immune responses is more limited than other types of cancers. The purpose of this study was to show that the efficacy of tumor primed antigen presenting macrophage vaccines could be increased by: (1) PDT of the priming tumor cells, and (2) injection of allogeneic glioma cells directly into brain tumors. Experiments were conducted in an in vivo brain tumor model using Fisher rats and BT4C (allogeneic) and F98 (syngeneic) glioma cells. Preliminary results showed that vaccination alone had significantly less inhibitory effect on F98 tumor growth compared to the combination of vaccination and allogeneic cell (BT4C) injection.

Paper Details

Date Published: 9 March 2016
PDF: 6 pages
Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96900D (9 March 2016); doi: 10.1117/12.2213569
Show Author Affiliations
Catherine E. Christie M.D., Beckman Laser Institute and Medical Clinic (United States)
Qian Peng M.D., Oslo Univ. Hospital (Norway)
Steen J. Madsen III, Univ. of Nevada, Las Vegas (United States)
Francisco A. Uzal, Univ. of California, Davis (United States)
Henry Hirschberg M.D., Beckman Laser Institute and Medical Clinic (United States)
Univ. of Nevada, Las Vegas (United States)


Published in SPIE Proceedings Vol. 9690:
Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation
Steen J. Madsen; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Victor X. D. Yang, Editor(s)

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