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Proceedings Paper

A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system
Author(s): Michele M. Kim; Rozhin Penjweini; Nathan R. Gemmell; Israel Veilleux; Aongus McCarthy; Gerald Buller; Robert H. Hadfield; Brian C. Wilson; Timothy C. Zhu
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Paper Abstract

An explicit dosimetry model has been developed to calculate the apparent reacted 1O2 concentration ([1O2]rx) in an in-vivo model. In the model, a macroscopic quantity, g, is introduced to account for oxygen perfusion to the medium during PDT. In this study, the SOED model is extended for PDT treatment in phantom conditions where vasculature is not present; the oxygen perfusion is achieved through the air-phantom interface instead. The solution of the SOED model is obtained by solving the coupled photochemical rate equations incorporating oxygen perfusion through the air-liquid interface. Experiments were performed for two photosensitizers (PS), Rose Bengal (RB) and Photofrin, in solution, using SOED and SOLD measurements to determine both the instantaneous [1O2] as well as cumulative [1O2]rx concentrations, where [1O2=(1/τ)•∫[1O2]dt. The PS concentrations varied between 10 and 100 mM for RB and ~200 mM for Photofrin. The resulting magnitudes of [1O2] were compared between SOED and SOLD.

Paper Details

Date Published: 1 March 2016
PDF: 9 pages
Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 969406 (1 March 2016); doi: 10.1117/12.2213236
Show Author Affiliations
Michele M. Kim, The Univ. of Pennsylvania Health System (United States)
Univ. of Pennsylvania (United States)
Rozhin Penjweini, The Univ. of Pennsylvania Health System (United States)
Nathan R. Gemmell, Univ. of Glasgow (United Kingdom)
Israel Veilleux, Princess Margaret Hospital (Canada)
Univ. of Toronto (Canada)
Aongus McCarthy, Heriot-Watt Univ. (United Kingdom)
Gerald Buller, Heriot-Watt Univ. (United Kingdom)
Robert H. Hadfield, Univ. of Glasgow (United Kingdom)
Brian C. Wilson, Princess Margaret Hospital (Canada)
Univ. of Toronto (Canada)
Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)


Published in SPIE Proceedings Vol. 9694:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
David H. Kessel; Tayyaba Hasan, Editor(s)

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