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Proceedings Paper

Real time imaging of peripheral nerve vasculature using optical coherence angiography
Author(s): Srikanth Vasudevan; Doe Kumsa; Pavel Takmakov; Cristin G. Welle; Daniel X. Hammer
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Paper Abstract

The peripheral nervous system (PNS) carries bidirectional information between the central nervous system and distal organs. PNS stimulation has been widely used in medical devices for therapeutic indications, such as bladder control and seizure cessation. Investigational uses of PNS stimulation include providing sensory feedback for improved control of prosthetic limbs. While nerve safety has been well documented for stimulation parameters used in marketed devices, novel PNS stimulation devices may require alternative stimulation paradigms to achieve maximum therapeutic benefit. Improved testing paradigms to assess the safety of stimulation will expedite the development process for novel PNS stimulation devices. The objective of this research is to assess peripheral nerve vascular changes in real-time with optical coherence angiography (OCA). A 1300-nm OCA system was used to image vasculature changes in the rat sciatic nerve in the region around a surface contacting single electrode. Nerves and vasculature were imaged without stimulation for 180 minutes to quantify resting blood vessel diameter. Walking track analysis was used to assess motor function before and 6 days following experiments. There was no significant change in vessel diameter between baseline and other time points in all animals. Motor function tests indicated the experiments did not impair functionality. We also evaluated the capabilities to image the nerve during electrical stimulation in a pilot study. Combining OCA with established nerve assessment methods can be used to study the effects of electrical stimulation safety on neural and vascular tissue in the periphery.

Paper Details

Date Published: 9 March 2016
PDF: 7 pages
Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96901D (9 March 2016); doi: 10.1117/12.2213160
Show Author Affiliations
Srikanth Vasudevan, U.S. Food and Drug Administration (United States)
Doe Kumsa, U.S. Food and Drug Administration (United States)
Medical Device Innovation Consortium (United States)
Pavel Takmakov, U.S. Food and Drug Administration (United States)
Cristin G. Welle, U.S. Food and Drug Administration (United States)
Univ. of Colorado Denver (United States)
Daniel X. Hammer, U.S. Food and Drug Administration (United States)

Published in SPIE Proceedings Vol. 9690:
Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation
Steen J. Madsen; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Victor X. D. Yang, Editor(s)

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