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Proceedings Paper

An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures
Author(s): Wenfeng Xia; Daniil I. Nikitichev; Jean Martial Mari; Simeon J. West; Sebastien Ourselin; Paul C. Beard; Adrien E. Desjardins
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Paper Abstract

Precise and efficient guidance of medical devices is of paramount importance for many minimally invasive procedures. These procedures include fetal interventions, tumor biopsies and treatments, central venous catheterisations and peripheral nerve blocks. Ultrasound imaging is commonly used for guidance, but it often provides insufficient contrast with which to identify soft tissue structures such as vessels, tumors, and nerves. In this study, a hybrid interventional imaging system that combines ultrasound imaging and multispectral photoacoustic imaging for guiding minimally invasive procedures was developed and characterized. The system provides both structural information from ultrasound imaging and molecular information from multispectral photoacoustic imaging. It uses a commercial linear-array ultrasound imaging probe as the ultrasound receiver, with a multimode optical fiber embedded in a needle to deliver pulsed excitation light to tissue. Co-registration of ultrasound and photoacoustic images is achieved with the use of the same ultrasound receiver for both modalities. Using tissue ex vivo, the system successfully discriminated deep-located fat tissue from the surrounding muscle tissue. The measured photoacoustic spectrum of the fat tissue had good agreement with the lipid spectrum in literature.

Paper Details

Date Published: 16 July 2015
PDF: 5 pages
Proc. SPIE 9539, Opto-Acoustic Methods and Applications in Biophotonics II, 95390D (16 July 2015); doi: 10.1117/12.2183798
Show Author Affiliations
Wenfeng Xia, Univ. College London (United Kingdom)
Daniil I. Nikitichev, Univ. College London (United Kingdom)
Jean Martial Mari, Univ. College London (United Kingdom)
Univ. of French Polynesia (French Polynesia)
Simeon J. West, Univ. College Hospital (United Kingdom)
Sebastien Ourselin, Univ. College London (United Kingdom)
Paul C. Beard, Univ College London (United Kingdom)
Adrien E. Desjardins, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 9539:
Opto-Acoustic Methods and Applications in Biophotonics II
Vasilis Ntziachristos; Roger Zemp, Editor(s)

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