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Proceedings Paper

Analysis and digital 3D modeling of long-range fourier-domain optical coherence tomography images of the pediatric subglottis
Author(s): Erica Su; Giriraj K. Sharma M.D.; Jason Chen; Tony D. Nguyen; Alex Wang; Ashley Hamamoto; Gurpreet S. Ahuja; Zhongping Chen; Brian J-F. Wong M.D.
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Paper Abstract

In neonatal and pediatric patients who require long-term endotracheal intubation, the subglottic mucosa is most susceptible to injury from the endotracheal tube. At present, there is no diagnostic modality to identify early signs of subglottic mucosal pathology. Fourier-domain optical coherence tomography (FD-OCT) is a minimally-invasive imaging modality which acquires high-resolution, 3D cross-sectional images of biological tissue. FD-OCT of the neonatal and pediatric airways was conducted to evaluate subglottic microanatomy and histopathologic changes associated with prolonged intubation. FD-OCT of the larynx, subglottis and proximal trachea was conducted in pediatric and neonatal patients. OCT image sets were analyzed by anatomic categorization (airway level), tissue segmentation and mucosa micrometry in MATLAB. Subsequently, OCT data sets were rendered into digital 3D airway models in Mimics software. We report original methods for subglottic OCT image processing and analysis.

Paper Details

Date Published: 31 March 2014
PDF: 8 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262J (31 March 2014); doi: 10.1117/12.2052793
Show Author Affiliations
Erica Su, Beckman Laser Institute (United States)
Giriraj K. Sharma M.D., Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)
Jason Chen, Beckman Laser Institute (United States)
Tony D. Nguyen, Beckman Laser Institute (United States)
Alex Wang, Beckman Laser Institute (United States)
Ashley Hamamoto, Beckman Laser Institute (United States)
Gurpreet S. Ahuja, Children’s Hospital of Orange County (United States)
Univ. of California, Irvine (United States)
Zhongping Chen, Beckman Laser Institute (United States)
Univ. of California Irvine (United States)
Brian J-F. Wong M.D., Beckman Laser Institute (United States)
Univ. of California Irvine (United States)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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