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Proceedings Paper

Photoacoustic and ultrasound dual-modality imaging for inflammatory arthritis
Author(s): Guan Xu; David Chamberland; Gandikota Girish; Xueding Wang
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Paper Abstract

Arthritis is a leading cause of disability, affecting 46 million of the population in the U.S. Rendering new optical contrast in articular tissues at high spatial and temporal resolution, emerging photoacoustic imaging (PAI) combined with more established ultrasound (US) imaging technologies provides unique opportunities for diagnosis and treatment monitoring of inflammatory arthritis. In addition to capturing peripheral bone and soft tissue images, PAI has the capability to quantify hemodynamic properties including regional blood oxygenation and blood volume, both abnormal in synovial tissues affected by arthritis. Therefore, PAI, especially when performed together with US, should be of considerable help for further understanding the pathophysiology of arthritis as well as assisting in therapeutic decisions, including assessing the efficacy of new pharmacological therapies. In this paper, we will review our recent work on the development of PAI for application to the diagnostic imaging and therapeutic monitoring of inflammatory arthritis. We will present the imaging results from a home-built imaging system and another one based on a commercial US. The performance of PAI in evaluating pharmacological therapy on animal model of arthritis will be shown. Moreover, our resent work on PAI and US dual-modality imaging of human peripheral joints in vivo will also be presented.

Paper Details

Date Published: 4 March 2014
PDF: 9 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 892643 (4 March 2014); doi: 10.1117/12.2047475
Show Author Affiliations
Guan Xu, Univ. of Michigan School of Medicine (United States)
David Chamberland, Univ. of Michigan School of Medicine (United States)
Gandikota Girish, Univ. of Michigan School of Medicine (United States)
Xueding Wang, Univ. of Michigan School of Medicine (United States)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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