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Proceedings Paper

Infrared fiber optic probes for evaluation of musculoskeletal tissue pathology
Author(s): Mugdha Padalkar; Cushla McGoverin; Quam Onigbanjo; Richard Spencer; Scott Barbash; Eric Kropf; Nancy Pleshko
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Paper Abstract

Musculoskeletal pathology of the knee commonly occurs with aging and as a result of injury. The incidence of anterior cruciate ligament (ACL) injuries continues to increase annually, and may precede the eventual onset of osteoarthritis (OA), a debilitating and prevalent disease characterized by cartilage degeneration. Early detection of OA remains elusive, with current imaging methods lacking adequate sensitivity to detect early pathologic cartilage changes. We used mid- and near- infrared (IR) spectroscopy through arthroscopic-based fiber-optic devices to assess cartilage damage and differentiate tendon from ligament. Mid-IR spectroscopy is characterized by distinct bands and low penetration depth (< 10 μm) and near-IR spectroscopy is characterized by complex overlapping bands and greater penetration depths (< 1 cm). We have found that combined mid- and near-IR analysis greatly extends the information available through either in the analysis of soft tissues, including cartilage, ligaments and tendons. We discuss here basic science studies and the potential for translation to clinical research with novel arthroscopic probes.

Paper Details

Date Published: 4 March 2014
PDF: 9 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89263Y (4 March 2014); doi: 10.1117/12.2047473
Show Author Affiliations
Mugdha Padalkar, Temple Univ. (United States)
Cushla McGoverin, Temple Univ. (United States)
Quam Onigbanjo, Temple Univ. (United States)
Richard Spencer, National Institutes of Health (United States)
Scott Barbash, Temple Univ. School of Medicine (United States)
Eric Kropf, Temple Univ. School of Medicine (United States)
Nancy Pleshko, Temple Univ. (United States)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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