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Proceedings Paper

A compact, inexpensive infrared laser system for continuous-wave optical stimulation of the rat prostate cavernous nerves
Author(s): William C. Perkins; Gwen A. Lagoda; Arthur L. Burnett M.D.; Nathaniel M. Fried
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Paper Abstract

Optical nerve stimulation (ONS) has been commonly performed in the laboratory using high-power, pulsed, infrared (IR) lasers including Holmium:YAG, diode, and Thulium fiber lasers. However, the relatively high cost of these lasers in comparison with conventional electrical nerve stimulation (ENS) equipment may represent a significant barrier to widespread adoption of ONS. Optical stimulation of the prostate cavernous nerves (CN’s) has recently been reported using lower cost, continuous-wave (CW), all-fiber-based diode lasers. This preliminary study describes further miniaturization and cost reduction of the ONS system in the form of a compact, lightweight, cordless, and inexpensive IR laser. A 140-mW, 1560-nm diode laser was integrated with a green aiming beam and delivery optics into a compact ONS system. Surface and subsurface ONS was performed in a total of 5 rats, in vivo, with measurement of an intracavernous pressure (ICP) response during CW laser irradiation for 30 s with a spot diameter of 0.7 mm. Short-term, CW ONS of the prostate CN’s is feasible using a compact, inexpensive, batterypowered IR laser diode system. This ONS system may represent an alternative to ENS for laboratory studies, and with further development, a handheld option for ONS in the clinic to identify and preserve the CN’s during prostate cancer surgery.

Paper Details

Date Published: 4 March 2014
PDF: 5 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89261E (4 March 2014); doi: 10.1117/12.2043189
Show Author Affiliations
William C. Perkins, The Univ. of North Carolina at Charlotte (United States)
Gwen A. Lagoda, Johns Hopkins Medical Institutions (United States)
Arthur L. Burnett M.D., Johns Hopkins Medical Institutions (United States)
Nathaniel M. Fried, The Univ. of North Carolina at Charlotte (United States)
Johns Hopkins Medical Institutions (United States)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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