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Proceedings Paper

Quantitative evaluation of atherosclerotic plaque phantom by near-infrared multispectral imaging with three wavelengths
Author(s): Ryo Nagao; Katsunori Ishii; Kunio Awazu
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Paper Abstract

Atherosclerosis is a primary cause of critical ischemic disease. The risk of critical event is involved the content of lipid in unstable plaque. Near-infrared (NIR) range is effective for diagnosis of atherosclerotic plaque because of the absorption peaks of lipid. NIR multispectral imaging (NIR-MSI) is suitable for the evaluation of plaque because it can provide spectroscopic information and spatial image quickly with a simple measurement system. The purpose of this study is to evaluate the lipid concentrations in plaque phantoms quantitatively with a NIR-MSI system. A NIR-MSI system was constructed with a supercontinuum light, a grating spectrometer and a MCT camera. Plaque phantoms with different concentrations of lipid were prepared by mixing bovine fat and a biological soft tissue model to mimic the different stages of unstable plaque. We evaluated the phantoms by the NIR-MSI system with three wavelengths in the band at 1200 nm. Multispectral images were processed by spectral angle mapper method. As a result, the lipid areas of phantoms were effectively highlighted by using three wavelengths. In addition, the concentrations of lipid areas were classified according to the similarity between measured spectra and a reference spectrum. These results suggested the possibility of image enhancement and quantitative evaluation of lipid in unstable plaque with a NIR-MSI.

Paper Details

Date Published: 4 March 2014
PDF: 6 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262V (4 March 2014); doi: 10.1117/12.2040889
Show Author Affiliations
Ryo Nagao, Osaka Univ. (Japan)
Katsunori Ishii, Osaka Univ. (Japan)
Kunio Awazu, Osaka Univ. (Japan)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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