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Proceedings Paper

Comparison of frequency domain optical coherence tomography and quantitative coronary angiography for the assessment of coronary lesions
Author(s): Haroon Zafar; Faisal Sharif; Martin J. Leahy
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Paper Abstract

Quantitative coronary angiography (QCA) has been used as a standard technique for the evaluation of coronary artery disease for many years. Intracoronary optical coherence tomography (OCT) offers higher resolution, faster image acquisition speeds and greater sensitivity than the intravascular ultrasound (IVUS). Recently developed frequency domain OCT (FD-OCT) systems overcome many technical limitations of conventional time domain OCT systems (TDOCT). The main objective of this study was to compare the FD-OCT and QCA measurements for the assessment of coronary lesions. A total of 21 stenoses in 18 patients were analysed using QCA and FD-OCT. The average minimum lumen diameter (MLD) and percent lumen area stenosis (%AS) by QCA were 1.52±0.44 mm and 68±9% respectively. The average MLD and %AS by FD-OCT were 1.32±0.38 mm and 63±14% respectively. There was a moderate but significant correlation between QCA and FD-OCT measured MLD (r = 0.5, p < 0.01) and %AS (r = 0.56, p < 0.01). Bland-Altman analysis showed that the mean differences between the QCA and FD-OCT measurements were 0.18±0.81 (limits of agreement: -0.63 to 0.99) for MLD and 4.4±22.8 (limits of agreement: -18.4 to 27.2) for %AS. The root mean square error (RMSE) between the QCA and FD-OCT measured MLD and %AS was ±0.44 mm and ±12.1% respectively.

Paper Details

Date Published: 4 March 2014
PDF: 5 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89263M (4 March 2014); doi: 10.1117/12.2040689
Show Author Affiliations
Haroon Zafar, National Univ. of Ireland, Galway (Ireland)
National Biophotonics and Imaging Platform (Ireland)
Faisal Sharif, Univ. Hospital Galway (Ireland)
National Univ. of Ireland, Galway (Ireland)
Bio Innovate (Ireland)
Martin J. Leahy, National Univ. of Ireland, Galway (Ireland)
National Biophotonics and Imaging Platform (Ireland)
Royal College of Surgeons (Ireland)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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