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Proceedings Paper

In vivo intra-operative breast tumor margin detection using a portable OCT system with a handheld surgical imaging probe
Author(s): Sarah J. Erickson-Bhatt; Ryan Nolan; Nathan D. Shemonski; Steven G. Adie; Jeffrey Putney; Donald Darga; Daniel T. McCormick; Andrew Cittadine; Marina Marjanovic; Eric J. Chaney; Guillermo L. Monroy; Fredrick South; P. Scott Carney; Kimberly A. Cradock; Z. George Liu; Partha S. Ray; Stephen A. Boppart
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Paper Abstract

Breast-conserving surgery is a frequent option for women with stage I and II breast cancer, and with radiation treatment, can be as effective as a mastectomy. However, adequate margin detection remains a challenge, and too often additional surgeries are required. Optical coherence tomography (OCT) provides a potential method for real-time, high-resolution imaging of breast tissue during surgery. Intra-operative OCT imaging of excised breast tissues has been previously demonstrated by several groups. In this study, a novel handheld surgical probe-based OCT system is introduced, which was used by the surgeon to image in vivo, within the tumor cavity, and immediately following tumor removal in order to detect the presence of any remaining cancer. Following resection, study investigators imaged the excised tissue with the same probe for comparison. We present OCT images obtained from over 15 patients during lumpectomy and mastectomy surgeries. Images were compared to post-operative histopathology for diagnosis. OCT images with micron scale resolution show areas of heterogeneity and disorganized features indicative of malignancy, compared to more uniform regions of normal tissue. Video-rate acquisition shows the inside of the tumor cavity as the surgeon sweeps the probe along the walls of the surgical cavity. This demonstrates the potential of OCT for real-time assessment of surgical tumor margins and for reducing the unacceptably high re-operation rate for breast cancer patients.

Paper Details

Date Published: 27 February 2014
PDF: 6 pages
Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89351C (27 February 2014); doi: 10.1117/12.2040315
Show Author Affiliations
Sarah J. Erickson-Bhatt, Univ. of Illinois at Urbana-Champaign (United States)
Ryan Nolan, Univ. of Illinois at Urbana-Champaign (United States)
Nathan D. Shemonski, Univ. of Illinois at Urbana-Champaign (United States)
Steven G. Adie, Univ. of Illinois at Urbana-Champaign (United States)
Jeffrey Putney, Diagnostic Photonics, Inc. (United States)
Donald Darga, Diagnostic Photonics, Inc. (United States)
Daniel T. McCormick, AdvancedMEMS (United States)
Andrew Cittadine, Diagnostic Photonics, Inc. (United States)
Marina Marjanovic, Univ. of Illinois at Urbana-Champaign (United States)
Eric J. Chaney, Univ. of Illinois at Urbana-Champaign (United States)
Guillermo L. Monroy, Univ. of Illinois at Urbana-Champaign (United States)
Fredrick South, Univ. of Illinois at Urbana-Champaign (United States)
P. Scott Carney, Univ. of Illinois at Urbana-Champaign (United States)
Diagnostic Photonics, Inc. (United States)
Kimberly A. Cradock, Carle Foundation Hospital (United States)
Z. George Liu, Carle Foundation Hospital (United States)
Partha S. Ray, Carle Foundation Hospital (United States)
Stephen A. Boppart, Univ. of Illinois at Urbana-Champaign (United States)
Diagnostic Photonics, Inc. (United States)
Carle Foundation Hospital (United States)


Published in SPIE Proceedings Vol. 8935:
Advanced Biomedical and Clinical Diagnostic Systems XII
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest M.D., Editor(s)

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