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Proceedings Paper

Mueller polarimetry for the detection of cancers
Author(s): E. Du; Honghui He; Nan Zeng; Yihong Guo; Minghao Sun; Hui Ma; Shaoxiong Liu; Minghua Li
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Paper Abstract

Polarization measurements allow one to enhance imaging contrast of superficial tissues and obtain new polarization sensitive parameters for better description of the micro- and macro- structural and optical properties of complex tissues. Since the majority of cancers originate in the epithelial layer, probing the morphological and pathological changes in the superficial tissues using an expended parameter set and with improved spatial resolution and contrasts will lead to new clues on the early clinical detection of cancers. In this wok, we carry out polarization imaging on cancerous tissues and look for cancer specific features. Using a scattering model, which approximates the anisotropic biological tissues to a mixture of spherical and cylindrical scatterers imbedded in birefringent ambient media, and a Monte Carlo simulation program, we examine the relationship between the micro-structure of the model and the characteristic polarization features. The studies help to understand the contrast mechanism of polarization sensitive measurements for different cancers and provide the basis for potential clinical applications.

Paper Details

Date Published: 27 February 2014
PDF: 7 pages
Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89350S (27 February 2014);
Show Author Affiliations
E. Du, Tsinghua Univ. (China)
Honghui He, Tsinghua Univ. (China)
Nan Zeng, Tsinghua Univ. (China)
Yihong Guo, Tsinghua Univ. (China)
Minghao Sun, Tsinghua Univ. (China)
Hui Ma, Tsinghua Univ. (China)
Shaoxiong Liu, Huazhong Univ. of Science and Technology (China)
Minghua Li, Huazhong Univ. of Science and Technology (China)

Published in SPIE Proceedings Vol. 8935:
Advanced Biomedical and Clinical Diagnostic Systems XII
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest M.D., Editor(s)

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