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Proceedings Paper

The Fluostick, a real hand-held system for near-infrared fluorescence image-guided surgery
Author(s): Paul Dorval; Norman Mangeret; Stephanie Guillermet; Christian Adrien Righini; Gabriele Barabino; Philippe Rizo; Patrick Poulet
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Paper Abstract

Near-infrared fluorescence image-guided surgery, FIGS, has lately shown a huge potential in oncologic and lymphatic related surgeries. In some indications such as liver or heart surgery, fluorescence-reachable anatomic structures are limited by the access to the surgical field. Nevertheless, most of the systems available on the market are too large to image the sides of cavities. Small devices are clearly required to improve workability of fluorescence imaging systems. The current work describes the development of an instrument and the results of its evaluation. In order to image narrow area, we developed a small size device consisting of an optical head connected to a control box. The whole system, optical head, control box and software, receives a CE mark for clinical procedures. Building on existing technologies, we simplified the fluorescence imaging system. It consists of a custom charged-coupled device camera, a high color rendering index visible LED illumination and a Class1 Laser fluorophore excitation. With a curved shape of 25x35x150mm, the optical head was designed as a true hand-held probe. The field of view varies from 5x3.75cm to 2x1.5cm. The device is able to collect and display the signal of 5pmol of IndoCyanine Green (ICG) with a spatial resolution down to 70μm at 25 frames per second. The system has been evaluated in pre-clinical and clinical procedures. The preclinical studies confirmed the ability of the system to visualize tumors in mice models. Clinical evaluations includes lymphedema investigations and surgical resections of tumors in colorectal cancer.

Paper Details

Date Published: 27 February 2014
PDF: 7 pages
Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89350F (27 February 2014); doi: 10.1117/12.2037577
Show Author Affiliations
Paul Dorval, iCube Lab., Univ. de Strasbourg, CNRS (France)
Fluoptics (France)
Norman Mangeret, Fluoptics (France)
Stephanie Guillermet, Fluoptics (France)
Christian Adrien Righini, Institut Albert Bonniot (France)
Univ. Joseph Fourier (France)
Univ. Hospital of Grenoble (France)
Gabriele Barabino, CHU Saint-Etienne (France)
Philippe Rizo, CEA-LETI (France)
Patrick Poulet, iCube Lab., Univ. de Strasbourg, CNRS (France)

Published in SPIE Proceedings Vol. 8935:
Advanced Biomedical and Clinical Diagnostic Systems XII
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest M.D., Editor(s)

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