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Proceedings Paper

Ex vivo evaluation of safety and efficacy of vaporization of the prostate using a 300 W high-power laser diode with the wavelength of 980 nm
Author(s): Junya Takada; Norihiro Honda; Hisanao Hazama; Kunio Awazu
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Paper Abstract

Laser vaporization of the prostate is one of the promising technique for less-invasive treatment of benign prostatic hyperplasia. However, shorter operative duration and higher hemostatic ability are expected. The wavelength of 980 nm offers a high simultaneous absorption by water and hemoglobin, so that it combines the efficient vaporization with good hemostasis. Therefore, we have evaluated the safety and efficacy of vaporization of the prostate using a recently developed 300 W high-power laser diode with the wavelength of 980 nm. First, validity of bovine prostate tissue as the sample was confirmed by measuring the optical properties of bovine and human prostate tissue using a double integrating sphere optical system. Next, contact and non-contact ex vivo irradiations were performed for various irradiation powers and times, and vaporized and coagulated depths were measured. In the contact irradiation, the vaporized depth at the power of 300 W was significantly deeper than that at the power of 100 W, while the difference was relatively smaller for the coagulated depths at 300 and 100 W. In the non-contact irradiation, coagulation as thick as that in the contact irradiation was observed almost without vaporization. Therefore, it is suggested that the treatment in the contact irradiation using the high-power laser diode can vaporize the prostate more efficiently without increasing the risk of perforation. Hemostasis with the coagulation would be possible in both irradiation methods. To prevent the postoperative perforation, operators need to understand the relationship between the coagulated depth and the irradiation conditions.

Paper Details

Date Published: 4 March 2014
PDF: 8 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89261B (4 March 2014); doi: 10.1117/12.2037524
Show Author Affiliations
Junya Takada, Osaka Univ. (Japan)
Norihiro Honda, Osaka Univ. (Japan)
Hisanao Hazama, Osaka Univ. (Japan)
Kunio Awazu, Osaka Univ. (Japan)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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