Share Email Print

Proceedings Paper

Widefield fluorescence imaging as an auxiliary tool to select the biopsy site for actinic cheilitis diagnosis
Author(s): C. Kurachi D.D.S.; A. Cosci; A. Takahama Jr.; K. B. F. C. Fontes; R. S. Azevedo
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Actinic cheilitis (AC) is considered a potentially malignant disorder that mainly affects the lower lip, and it is caused by prolonged sun exposure. Clinical diagnosis relies on visual inspection by a trained clinician, when suspected of dysplasia changes, a biopsy is required. The heteregenous characteristics of the AC, makes the choice of the biopsy site a difficult task. Fluorescence detection has been presented as a useful tool to to detect biochemical and morphological tissue features related to cancer diagnosis, but still its effectiveness to discriminate premalignant lesion is not completely defined. In this clinical study, 57 AC patients were investigated using widefield fluorescence imaging (WFI) to evaluate the efficacy of this technique as an auxiliary tool to biopsy site location. A handheld fluorescence system based on 400-450 nm LED illumination Distinct trained clinicians evaluate the patient either with the conventional examination or the WFI, and were blinded to the other evaluation. A biopsy site was chosen based on the clinical examination, and another site was chosen using the fluorescence visualization. A total of 114 punch biopsies were performed, and 93% of the tissue samples presented epithelial dysplasia. The majority of the sites that presented moderate or severe dysplasia were sites chosen by WFI, showing its efficiency to improve the diagnosis of AC.

Paper Details

Date Published: 4 March 2014
PDF: 6 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 892627 (4 March 2014); doi: 10.1117/12.2037365
Show Author Affiliations
C. Kurachi D.D.S., Univ. de São Paulo (Brazil)
A. Cosci, Univ. de São Paulo (Brazil)
A. Takahama Jr., Univ. Federal Fluminense (Brazil)
K. B. F. C. Fontes, Univ. Federal Fluminense (Brazil)
R. S. Azevedo, Univ. Federal Fluminense (Brazil)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?