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Proceedings Paper

Combining the diffusion approximation and Monte Carlo modeling in analysis of diffuse reflectance spectra from human skin
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Paper Abstract

Light propagation in highly scattering biological tissues is often treated in the so-called diffusion approximation (DA). Although the analytical solutions derived within the DA are known to be inaccurate near tissue boundaries and absorbing layers, their use in quantitative analysis of diffuse reflectance spectra (DRS) is quite common. We analyze the artifacts in assessed tissue properties which occur in fitting of numerically simulated DRS with the DA solutions for a three-layer skin model. In addition, we introduce an original procedure which significantly improves the accuracy of such an inverse analysis of DRS. This procedure involves a single comparison run of a Monte Carlo (MC) numerical model, yet avoids the need to implement and run an inverse MC. This approach is tested also in analysis of experimental DRS from human skin.

Paper Details

Date Published: 4 March 2014
PDF: 13 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89260U (4 March 2014); doi: 10.1117/12.2035747
Show Author Affiliations
Peter Naglič, Univ. of Ljubljana (Slovenia)
Luka Vidovič, Jožef Stefan Institute (Slovenia)
Matija Milanič, Jožef Stefan Institute (Slovenia)
Lise L. Randeberg, Norwegian Univ. of Science and Technology (Norway)
Boris Majaron, Jožef Stefan Institute (Slovenia)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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