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Proceedings Paper

A non-contact time-domain scanning brain imaging system: first in-vivo results
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Paper Abstract

We present results of first in-vivo tests of an optical non-contact scanning imaging system, intended to study oxidative metabolism related processes in biological tissue by means of time-resolved near-infrared spectroscopy. Our method is a novel realization of the short source-detector separation approach and based on a fast-gated single-photon avalanche diode to detect late photons only. The scanning system is built in quasi-confocal configuration and utilizes polarizationsensitive detection. It scans an area of 4×4 cm2, recording images with 32×32 pixels, thus creating a high density of source-detector pairs. To test the system we performed a range of in vivo measurements of hemodynamic changes in several types of biological tissues, i.e. skin (Valsalva maneuver), muscle (venous and arterial occlusions) and brain (motor and cognitive tasks). Task-related changes in hemoglobin concentrations were clearly detected in skin and muscle. The brain activation shows weaker, but yet detectable changes. These changes were localized in pixels near the motor cortex area (C3). However, it was found that even very short hair substantially impairs the measurement. Thus the applicability of the scanner is limited to hairless parts of body. The results of our first in-vivo tests prove the feasibility of non-contact scanning imaging as a first step towards development of a prototype for biological tissue imaging for various medical applications.

Paper Details

Date Published: 14 June 2013
PDF: 7 pages
Proc. SPIE 8799, Diffuse Optical Imaging IV, 87990L (14 June 2013); doi: 10.1117/12.2032386
Show Author Affiliations
M. Mazurenka, Physikalisch-Technische Bundesanstalt (Germany)
L. Di Sieno, Politecnico di Milano (Italy)
G. Boso, Politecnico di Milano (Italy)
D. Contini, Politecnico di Milano (Italy)
A. Pifferi, Politecnico di Milano (Italy)
A. Dalla Mora, Politecnico di Milano (Italy)
A. Tosi, Politecnico di Milano (Italy)
H. Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
R. Macdonald, Physikalisch-Technische Bundesanstalt (Germany)

Published in SPIE Proceedings Vol. 8799:
Diffuse Optical Imaging IV
Paola Taroni; Hamid Dehghani, Editor(s)

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