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Proceedings Paper

Blood flow velocity measurement by endovascular Doppler optical coherence tomography
Author(s): Cuiru Sun; Felix Nolte; Barry Vuong; Kyle H. Y. Cheng; Kenneth K. C. Lee; Beau A. Standish; Brian Courtney M.D.; Tom R. Marotta; Victor X. D. Yang
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Paper Abstract

Blood flow velocity and volumetric flow measurements are important parameters for assessment of the severity of stenosis and the outcome of interventional therapy. However, feasibility of intravascular flow measurement using a rotational catheter based phase resolved Doppler optical coherence tomography (DOCT) is difficult. Motion artefacts induced by the rotating optical imaging catheter, and the radially dependent noise background of measured Doppler signals are the main challenges encountered. In this study, a custom-made data acquisition system and developed algorithms to remove non-uniform rotational distortion (NURD) induced phase shift artefact by tracking the phase shift observed on catheter sheath. The flow velocity is calculated from Doppler shift obtained by Kasai autocorrelation after motion artefact removal. Blood flow velocity profiles in porcine carotid arteries in vivo were obtained at 100 frames/s with 500 A-lines/frame and DOCT images were taken at 20 frames/s with 2500 A-lines/frame. Time-varying velocity profiles were obtained at an artery branch. Furthermore, the identification of a vein adjacent to the catheterized vessel based on the color Doppler signal was also observed. The absolute measurement of intravascular flow using a rotating fiber catheter can provide insights to different stages of interventional treatment of stenosis in carotid artery.

Paper Details

Date Published: 8 March 2013
PDF: 6 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85654S (8 March 2013); doi: 10.1117/12.2019244
Show Author Affiliations
Cuiru Sun, Ryerson Univ. (Canada)
Univ. of Toronto (Canada)
Felix Nolte, Ryerson Univ. (Canada)
The Univ. of Applied Sciences (Germany)
Barry Vuong, Ryerson Univ. (Canada)
Kyle H. Y. Cheng, Ryerson Univ. (Canada)
The Univ. of Toronto (Canada)
Kenneth K. C. Lee, Ryerson Univ. (Canada)
The Univ. of Toronto (Canada)
Beau A. Standish, Ryerson Univ. (Canada)
Brian Courtney M.D., Colibri Technologies Inc. (Canada)
Tom R. Marotta, St. Michael's Hospital (Canada)
Victor X. D. Yang, Ryerson Univ. (Canada)
The Univ. of Toronto (Canada)
St. Michael's Hospital (Canada)

Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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